How to set up a strat for slide guitar

1. Does intonation matter on a slide guitar?

Does intonation matter on a slide guitar?

Thicker strings and higher action, intonation is all done on the fly with a slide. If you're setting up for slide-only, you'd want a new nut with significantly higher action. Mostly you'd want a normal setup with thicker strings and jack up your action a tad, that way you can combine slide and regular licks.