Colorectal cancer microbiome

1: Microbiota-associated mechanisms involved in the pathogenesis of colorectal cancer. The gut microbiota can influence colorectal carcinogenesis via a variety of mechanisms, including microbial-derived factors such as metabolites or genotoxins.

1. How does the microbiome contribute to colon cancer development?
2. What bacteria is associated with colon cancer?
3. Is the microbiome in the colon?
4. How does gut microbiota cause cancer?

How does the microbiome contribute to colon cancer development?

Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression by modulating mechanisms such as inflammation and DNA damage, and by producing metabolites involved in tumor progression or suppression.

What bacteria is associated with colon cancer?

Background: Streptococcus bovis bacteremia is classically associated with colorectal cancer. A number of other bacterial species have been found in colorectal cancer microbiota and may even exert oncogenic effects.

Is the microbiome in the colon?

Ninety-five percent of the body's microbiota reside in the gut, primarily in the colon where microbial cells outnumber the total cells in the human body (4). Using available sequencing methods, it is now possible to determine the presence of healthy or disarrayed microbiomes.

How does gut microbiota cause cancer?

Gut microbiota exacerbate metabolic inflammation through TLR signaling [64]. For example, the LPS receptor TLR4 has been shown to promote hepatocellular carcinoma, pancreatic cancer, and colon cancer. TLR-induced activation of NF-kB and STAT3 is a key signaling pathway that promotes cancer [32].