Tubes will make a myriad of strange and seemingly inexplicable sounds. ... That's pretty rare, but if it does happen you'll need to replace the power tubes. More often than not, when your amp is making a humming sound, it's caused by dirty power, a bad ground connection, or fluorescent lighting.
Why is my amp making a buzzing noise?
A healthy amp is likely to make some sort of noise when idle. ... Poor quality pedal boards, FX units or even guitars will feed noise into the amp that will be exponentially amplified. If the AC supply is poor or your outlet is not earthed well enough then it can create a humming or buzzing sound.